Now open as of August 2026

Where sacred meets science

We are a fully regulated, psilocybin therapy retreat centre located in Centennial, Colorado

Book a consult

Safe and supportive individual and group therapy retreats.

Guided, evidence-informed process that thoughtfully pairs natural psychedelic medicine with expert therapeutic support.

Careful preparation, supported sessions, and intentional integration.

For Individuals

A complete, guided psilocybin healing experience designed around you

→

For Groups

Shared healing experiences for groups of 4–8 participants in a communal, supported setting

→

Retreats

Immersive multi-day healing experiences combining ceremony, integration, community, and rest

→

What participants say

For Medical Professionals

Your patients deserve every option. We make one more possible.

We work with referring clinicians to provide a structured, documented pathway for patients with treatment-resistant conditions — and offer continuing education for practitioners who want to understand the clinical evidence.

Refer a patientRead the clinical research →

Our people

The people behind Zephyr

Meet the full team
Annmarie Kropp

Co-Founder & President

Annmarie Kropp

Over a decade of somatic therapy practice and a deep personal commitment to integrating contemplative and clinical approaches to healing.

Alessio Luinetti

Co-Founder & Medical Director

Alessio Luinetti, MD

Practising psychiatrist with clinical research experience in psychedelic-assisted therapy. Oversees all medical protocols and participant screening at Zephyr.

Emily Sisa

Co-Founder & Director of Psychedelic Programming

Emily Sisa

Specialises in post-session integration, helping clients weave the insights from their experience into lasting change across relationships, work, and identity.

The evidence

The mystical experience is not a side effect. It is the mechanism.

Across more than a decade of controlled clinical research, one finding has emerged with unusual consistency: the intensity of the spiritual or mystical experience during a psilocybin session is one of the strongest predictors of therapeutic outcome. We built our model on what that literature shows.

58%

of participants rated the experience among the five most personally meaningful of their lives at 14-month follow-up

Griffiths et al., 2006 — double-blind RCT

67%

rated the experience among the five most spiritually significant of their lives — same cohort, 14 months later

Griffiths et al., 2008

71–100%

of cancer patients attributed positive life changes to their experience at 4.5-year long-term follow-up

Agin-Liebes et al., 2020

10 of 12

psychedelic therapy studies found a significant association between mystical experience intensity and symptom reduction

Ko et al., Frontiers in Psychiatry, 2022

Research drawn from

Johns Hopkins UniversityFrontiers in PsychiatryJournal of PsychopharmacologyNature, 2024Acta Psychiatrica Scandinavica
Read the research

Common questions

What you need to know

View all FAQs
Is psilocybin therapy legal in Colorado?+

Yes. Colorado's Proposition 122, passed in November 2022, legalised the regulated use of psilocybin for adults at licensed healing centres. Zephyr operates under a full licence issued by the Colorado Department of Regulatory Agencies (DORA), which oversees all natural medicine health services in the state.

Who is a good candidate for psilocybin therapy?+

Psilocybin therapy may be helpful for adults experiencing depression, anxiety, PTSD, existential distress, or those seeking deeper personal growth. Every prospective participant completes a thorough intake process — including a medical screening and consultation with our clinical team — to ensure the program is a safe and appropriate fit.

What does a typical program look like?+

Our programs are structured in three phases: preparation (2–3 sessions to build a therapeutic alliance, set intentions, and address any concerns), the psilocybin experience itself (a full-day session at our Centennial centre with two trained facilitators present), and integration (follow-up sessions to help you make meaning of the experience and carry insights forward).

Are there any contraindications?+

Psilocybin therapy is not recommended for individuals with a personal or family history of psychosis or schizophrenia, those currently taking lithium or certain SSRIs, or those who are pregnant or breastfeeding. Our medical intake process is designed to identify any contraindications safely and without judgement.

How do I get started?+

Begin by booking a free 20-minute consultation with a member of our clinical team. This is a no-pressure conversation to answer your questions, understand your history, and discuss whether Zephyr is the right fit. You can book directly through our website or by calling our Centennial centre.