Your Questions, Answered

  • Psilocybin-assisted therapy is a structured mental health treatment that combines the use of regulated psilocybin with professional preparation, supervised administration, and integration sessions. Psilocybin is a naturally occurring psychedelic compound that may support insight, emotional processing, and psychological flexibility when used in a safe, therapeutic setting.

  • Yes. While psilocybin remains a federally controlled substance, these services are lawful under Colorado state law.

    Psilocybin-assisted therapy is permitted under Colorado’s Natural Medicine Health Act when provided through a regulated program and delivered according to state guidelines.

    Zephyr Collective operates in alignment with all applicable Colorado regulations.

  • At this time, psilocybin-assisted therapy is not covered by insurance. Zephyr Collective can provide transparent self-pay pricing and discuss payment options during your intake.

    Integration and preparatory therapy sessions may be billable through insurance depending on facilitator or licensed mental health mental health professional.

  • Psilocybin-assisted therapy may be helpful for individuals experiencing:

    • Depression or treatment-resistant depression

    • Anxiety, including existential or end-of-life anxiety

    • Trauma or PTSD

    • Burnout, grief, or life transitions

    • Desire for deeper self-exploration or emotional insight

    Participation requires a comprehensive screening to determine medical, psychiatric, and psychological appropriateness.

    Research suggests psilocybin may support insight, emotional processing, and personal growth when used in structured, supportive settings.

  • Item descriptionPsilocybin-assisted therapy may not be appropriate for individuals with:

    • A personal or strong family history of psychotic disorders (e.g., schizophrenia, schizoaffective disorder)

    • Uncontrolled bipolar I disorder

    • Active substance use disorders without stability

    • Certain cardiac or neurological conditions

    • Pregnancy or breastfeeding

    Final eligibility is determined through a clinical evaluation and screening process.

  • The process generally includes:

    1. Initial screening and intake

    2. Preparation sessions to establish intentions, review safety, and build therapeutic rapport

    3. Supervised psilocybin session in a safe, supportive setting

    4. Integration sessions to process insights and apply them meaningfully to daily life

    Psilocybin is never provided without appropriate preparation and follow-up.

  • During the dosing session, you are supported by trained facilitators in a calm, intentional environment. Sessions typically last several hours. You may experience changes in perception, emotions, memory, or insight. The focus is on safety, emotional support, and allowing the experience to unfold without pressure or expectation.

  • Most individuals remain aware of their surroundings and are able to communicate throughout the experience. While experiences can be emotionally intense or deeply reflective, facilitators are present at all times to support you. The setting is designed to feel safe, grounded, and respectful.

  • No. Psilocybin-assisted therapy is fundamentally different from recreational use. It is:

    • Structured and intentional

    • Clinically screened

    • Facilitated by trained professionals

    • Integrated into a therapeutic process

    The goal is healing, insight, and integration — not escape or entertainment.

  • Preparation may include:

    • Setting intentions

    • Adjusting certain medications (when clinically appropriate)

    • Lifestyle recommendations prior to the session

    • Education on what to expect emotionally and physically

    Your care team will guide you through this process.

  • Integration involves making sense of your experience and applying insights to your life in a healthy, grounded way. This may include therapy sessions, journaling, behavioral changes, or mindfulness practices. Integration is often where lasting change occurs.

  • Psilocybin is generally well-tolerated in screened individuals when used in a controlled setting. Possible side effects may include:

    • Temporary anxiety or emotional intensity

    • Nausea or headache

    • Fatigue after the session

    Serious adverse events are rare when proper screening and supervision are in place.

  • This varies by individual and goals. Some people benefit from a single experience with integration, while others may engage in a longer therapeutic process. Your treatment plan will be individualized.

  • Psilocybin services offered under Colorado’s Natural Medicine framework are not federally regulated medical treatments and are distinct from traditional psychiatric or medical care.

    These services:

    • Do not involve prescribing medication

    • Are not billed to insurance

    • Do not replace psychotherapy, psychiatric care, or medication management

    • Are offered as facilitated services, not medical interventions

    Clients are encouraged to continue working with their existing healthcare providers before, during, and after participation.

  • Psilocybin services offered under Colorado’s Natural Medicine framework are not federally regulated medical treatments and are distinct from traditional psychiatric or medical care.

    These services:

    • Do not involve prescribing medication

    • Are not billed to insurance

    • Do not replace psychotherapy, psychiatric care, or medication management

    • Are offered as facilitated services, not medical interventions

    Clients are encouraged to continue working with their existing healthcare providers before, during, and after participation.

  • Psilocybin-assisted therapy can sometimes complement existing care, but coordination is important. We encourage collaboration with your current mental health providers when appropriate and safe.

  • Some medications can alter the effects, safety, or effectiveness of psilocybin-assisted therapy. During your screening process, we carefully review all prescription medications, over-the-counter medications, and supplements you are taking.

    Certain medications may:

    • Reduce or blunt the therapeutic effects of psilocybin

    • Increase the risk of side effects

    • Require temporary adjustment, tapering, or additional monitoring

    • Make psilocybin-assisted therapy not appropriate at this time

    Common medication categories that may require special consideration include:

    • Antidepressants (such as SSRIs, SNRIs, and tricyclics)

    • Mood stabilizers

    • Antipsychotic medications

    • Benzodiazepines

    • Stimulant medications

    • MAOIs and other serotonergic agents

    Medication changes are never required automatically and are never made without careful clinical consideration. Any recommendations regarding medication adjustments are discussed collaboratively and prioritized around safety and mental health stability.

  • Not necessarily. Some individuals can safely participate while continuing certain medications, while others may benefit from adjustments. In some cases, psilocybin-assisted therapy may not be recommended if stopping a medication would pose a risk to your health.

    Zephyr Collective does not require medication discontinuation unless it is clinically appropriate and agreed upon after thorough discussion.

  • Medication management depends on your care structure. We may:

    • Coordinate with your current prescribing provider

    • Provide guidance and education around medication considerations

    • Recommend consultation with a medical or psychiatric provider when needed

    Any medication changes must be managed by a licensed prescribing clinician.

  • hat’s completely okay and very common. Medication compatibility is addressed during the intake and preparation process. Our goal is to ensure your experience is safe, ethical, and therapeutically appropriate, not to rush or pressure participation.

  • We combine a thoughtful, human-centered approach with clear communication and reliable results. It’s not just what we do it’s how we do it that sets us apart.

  • Collaborative, honest, and straightforward. We're here to guide the process, bring ideas to the table, and keep things moving.

  • You can begin by scheduling a consultation. Our team will guide you through next steps and answer any additional questions.

  • You can reach us anytime via our contact page or email. We aim to respond quickly usually within one business day.